Manchester City defeated Crystal Palace 3-1 courtesy of a brace from Raheem Sterling and a lone goal by Gabriel Jesus.
Sterling opened the scoring with a stunning goal in the 15th minute before adding the second goal in the 63rd minute.
Gabriel Jesus wrapped up the victory in the 90th minute to give Manchester City the maximum points.
Milojevic scored a consolation for Crystal Palace in the 81st minute, thus becoming the first player to score against City home and away this season.
Manchester City manager Pep Guardiola praised his players for responding well after the champions league defeat against Tottenham.
“Today’s game was really good after the Champions League defeat – the stage was not easy.
“We play December, January, February – every three days one game. Why not trust the guys to do it again. We have the personality for the games.
“I knew we would produce a good performance.”
Manchester City have won five away Premier League games against London sides this season, their highest ever number of victories in the capital within a single top-flight campaign.
The Defending Champions will slug it out with Tottenham for a place in the Uefa Champions League Semi Final on Wednesday at the Etihad Stadium.